三重再攝取抑制劑
 | 此條目需要擴充。 (2015年9月29日) |
血清素-去甲腎上腺素-多巴胺再攝取抑制劑（英語：serotonin–norepinephrine–dopamine reuptake inhibitor，SNDRI），也稱作三重再攝取抑制劑（TRI），是多種單胺類神經遞質的再攝取抑制劑，原理為通過抑制5-羥色胺轉運體、去甲腎上腺素轉運體和多巴胺轉運體體來分別抑制5-羥色胺、 去甲腎上腺素和多巴胺的再攝取。這個作用會增加這些神經遞質在突觸間隙的濃度。
SNDRI作為一系列疾病的藥物候選而被開發，如抗憂鬱劑[1][2][3][4][5] 和治療肥胖、古柯鹼成癮、注意力缺陷/過動症(ADHD)及慢性疼痛的藥物。SNDRI作為選擇性血清素再吸收抑制劑(SSRIs)及血清素-去甲腎上腺素再吸收抑制劑(SNRIs)的延伸，增加了多巴胺的再吸收抑制作用，這被認為具有增加療效的可能，但副作用及藥物濫用的可能也隨之增加。
引用
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