BNN-27

BNN-27
臨床資料
其他名稱	BNN27; (20R)-3β,21-Dihydroxy-17α,20-epoxypregn-5-ene; 17α,20R-Epoxypregn-5-ene-3β,21-diol
識別資訊
	IUPAC命名法 (3S,8R,9S,10R,13S,14S,17R)-3'-(Hydroxymethyl)-10,13-dimethylspiro[1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,2'-oxirane]-3-ol; ;
PubChem CID	25154755;
ChemSpider	24660621;
化學資訊
化學式	C21H32O3
摩爾質量	332.48 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]45C(O5)CO)C)O;
	InChI InChI=1S/C21H32O3/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20)18(12-22)24-21/h3,14-18,22-23H,4-12H2,1-2H3/t14-,15+,16-,17-,18?,19-,20-,21-/m0/s1; Key:FMOHTQBFGJULLE-HNFJNZPISA-N;

BNN-27（化學名：17α,20R-環氧孕甾-5-烯-3β,21-二醇，英語：17α,20R-epoxypregn-5-ene-3β,21-diol）是一種有機化合物，化學式C
21H
32O
3，是一種人工合成的神經甾體。^[1]^[2]^[3]^[4]

參考文獻

^ Calogeropoulou T, Avlonitis N, Minas V, Alexi X, Pantzou A, Charalampopoulos I, Zervou M, Vergou V, Katsanou ES, Lazaridis I, Alexis MN, Gravanis A. Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity. J. Med. Chem. 2009, 52 (21): 6569–87. PMID 19845386. doi:10.1021/jm900468p.
^ Pediaditakis I, Efstathopoulos P, Prousis KC, Zervou M, Arévalo JC, Alexaki VI, Nikoletopoulou V, Karagianni E, Potamitis C, Tavernarakis N, Chavakis T, Margioris AN, Venihaki M, Calogeropoulou T, Charalampopoulos I, Gravanis A. Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation. Neuropharmacology. 2016, 111: 266–282. PMID 27618740. S2CID 3810489. doi:10.1016/j.neuropharm.2016.09.007.
^ Pediaditakis I, Kourgiantaki A, Prousis KC, Potamitis C, Xanthopoulos KP, Zervou M, Calogeropoulou T, Charalampopoulos I, Gravanis A. BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis. Front Pharmacol. 2016, 7: 512. PMC 5183592 . PMID 28082899. doi:10.3389/fphar.2016.00512 .
^ Pitsikas N, Gravanis A. The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats. Neurobiol Learn Mem. 2017, 140: 145–153. PMID 28274826. S2CID 3459637. doi:10.1016/j.nlm.2017.03.004.