BNN-27

BNN-27
临床资料
其他名称	BNN27; (20R)-3β,21-Dihydroxy-17α,20-epoxypregn-5-ene; 17α,20R-Epoxypregn-5-ene-3β,21-diol
识别信息
	IUPAC命名法 (3S,8R,9S,10R,13S,14S,17R)-3'-(Hydroxymethyl)-10,13-dimethylspiro[1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,2'-oxirane]-3-ol; ;
PubChem CID	25154755;
ChemSpider	24660621;
化学信息
化学式	C21H32O3
摩尔质量	332.48 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]45C(O5)CO)C)O;
	InChI InChI=1S/C21H32O3/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20)18(12-22)24-21/h3,14-18,22-23H,4-12H2,1-2H3/t14-,15+,16-,17-,18?,19-,20-,21-/m0/s1; Key:FMOHTQBFGJULLE-HNFJNZPISA-N;

BNN-27（化学名：17α,20R-环氧孕甾-5-烯-3β,21-二醇，英语：17α,20R-epoxypregn-5-ene-3β,21-diol）是一种有机化合物，化学式C
21H
32O
3，是一种人工合成的神经甾体。^[1]^[2]^[3]^[4]

参考文献

^ Calogeropoulou T, Avlonitis N, Minas V, Alexi X, Pantzou A, Charalampopoulos I, Zervou M, Vergou V, Katsanou ES, Lazaridis I, Alexis MN, Gravanis A. Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity. J. Med. Chem. 2009, 52 (21): 6569–87. PMID 19845386. doi:10.1021/jm900468p.
^ Pediaditakis I, Efstathopoulos P, Prousis KC, Zervou M, Arévalo JC, Alexaki VI, Nikoletopoulou V, Karagianni E, Potamitis C, Tavernarakis N, Chavakis T, Margioris AN, Venihaki M, Calogeropoulou T, Charalampopoulos I, Gravanis A. Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation. Neuropharmacology. 2016, 111: 266–282. PMID 27618740. S2CID 3810489. doi:10.1016/j.neuropharm.2016.09.007.
^ Pediaditakis I, Kourgiantaki A, Prousis KC, Potamitis C, Xanthopoulos KP, Zervou M, Calogeropoulou T, Charalampopoulos I, Gravanis A. BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis. Front Pharmacol. 2016, 7: 512. PMC 5183592 . PMID 28082899. doi:10.3389/fphar.2016.00512 .
^ Pitsikas N, Gravanis A. The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats. Neurobiol Learn Mem. 2017, 140: 145–153. PMID 28274826. S2CID 3459637. doi:10.1016/j.nlm.2017.03.004.