CYP51A1
| Cytochrome P450, Family 51, Subfamily A, Polypeptide 1 | |
|---|---|
| 识别 | |
| 符号 | CYP51A1 |
| 替换符号 | CYP51, P45014DM |
| Entrez | 1595 |
| HUGO | 2649 |
| OMIM | 601637 |
| RefSeq | NM_000786 |
| UniProt | Q16850 |
| 其他数据 | |
| EC编号 | 1.14.14.154 |
| 基因座 | 7 q21.2-21.3 |
细胞色素 P450 51A1（英语：Cytochrome P450 27A1，缩写CYP51A1）也被称为羊毛甾醇-14α-脱甲基酶（Lanosterol 14α-demethylase，EC 1.14.14.154），是细胞色素P450超家族的一员，在人类基因组中由CYP51A1基因编码，可催化带有14α甲基的甾醇（如羊毛甾醇）去甲基化并D环上的C14-C15脱氢生成对应的甾醇（如4,4-二甲基胆甾-8(9),14,24-三烯-3β-醇）[6]。在后鞭毛生物（包括动物和真菌）的胆固醇合成中，CYP51A1催化2,3-环氧鲨烯成环后的第一步反应，是参与甾体生成的第一个CYP酶[7]。
进化
[编辑]CYP51A1所属的CYP51家族是进化上较保守的家族[8]，在功能上都催化对应甾醇的14α脱甲基化[9]，在真核域和细菌域中都广泛存在，但不同生物界之间CYP51的相似性只有22-30%[10]。
参考文献
[编辑]- ^ 對cytochrome P450 family 51 subfamily A member 1起作用的藥物；在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000001630 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000001467 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Metabocard for 4,4-Dimethylcholesta-8,14,24-trienol (HMDB01023). Human Metabolome Database. February 2014 [2020-04-18]. （原始内容存档于2017-12-26）.
- ^ Lepesheva GI, Waterman MR. Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms. Biochimica et Biophysica Acta. March 2007, 1770 (3): 467–77. PMC 2324071
. PMID 16963187. doi:10.1016/j.bbagen.2006.07.018.
- ^ Lepesheva GI, Waterman MR. CYP51--the omnipotent P450. Molecular and Cellular Endocrinology. February 2004, 215 (1–2): 165–70. PMID 15026190. doi:10.1016/j.mce.2003.11.016.
- ^ Becher R, Wirsel SG. Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens. Applied Microbiology and Biotechnology. August 2012, 95 (4): 825–40. PMID 22684327. doi:10.1007/s00253-012-4195-9.
- ^ Lepesheva GI, Waterman MR. Structural basis for conservation in the CYP51 family. Biochimica et Biophysica Acta. January 2011, 1814 (1): 88–93. PMC 2962772 . PMID 20547249. doi:10.1016/j.bbapap.2010.06.006.
