膽固醇側鏈裂解酶
膽固醇側鏈裂解酶（英語：Cholesterol side-chain cleavage enzyme，CYP11A1或P450scc，其中「scc」是「side-chain 側鏈」「cleavage 裂解」的縮寫）是一種將膽固醇轉化為孕烯醇酮的線粒體酶。這是所有哺乳動物中由膽固醇生成各種甾類激素的第一步反應[7]。
P450scc 是細胞色素P450氧化酶超家族的一員（家族11亞家族A多肽1），基因名為 CYP11A1[8]。
另見
[編輯]參考文獻
[編輯]- ^ 與胆固醇侧链裂解酶相關的疾病；在維基數據上查看/編輯參考.
- ^ 對胆固醇侧链裂解酶起作用的藥物；在維基數據上查看/編輯參考.
- ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000140459、ENSG00000288362 - Ensembl, May 2017
- ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000032323 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hanukoglu I. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis. The Journal of Steroid Biochemistry and Molecular Biology. December 1992, 43 (8): 779–804. PMID 22217824. doi:10.1016/0960-0760(92)90307-5.
- ^ Entrez Gene: CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1.
延伸閱讀
[編輯]- Helmberg A. Twin genes and endocrine disease: CYP21 and CYP11B genes. Acta Endocrinologica. August 1993, 129 (2): 97–108. PMID 8372604. doi:10.1530/acta.0.1290097.
- Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversa JL, Bernassau JM, Drieu K. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids. January 1997, 62 (1): 21–8. PMID 9029710. doi:10.1016/S0039-128X(96)00154-7.
- Stocco DM. Intramitochondrial cholesterol transfer. Biochimica et Biophysica Acta. June 2000, 1486 (1): 184–97. PMID 10856721. doi:10.1016/S1388-1981(00)00056-1.
- Kristensen VN, Kure EH, Erikstein B, Harada N, Børresen-Dale A. Genetic susceptibility and environmental estrogen-like compounds. Mutation Research. October 2001, 482 (1–2): 77–82. PMID 11535251. doi:10.1016/S0027-5107(01)00212-3.
- Strauss JF. Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome. Annals of the New York Academy of Sciences. November 2003, 997 (1): 42–8. PMID 14644808. doi:10.1196/annals.1290.005.
- Wada A, Waterman MR. Identification by site-directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding. The Journal of Biological Chemistry. November 1992, 267 (32): 22877–82. PMID 1429635.
- Hu MC, Guo IC, Lin JH, Chung BC. Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein. The Biochemical Journal. March 1991, 274 (Pt 3): 813–7. PMC 1149983
. PMID 1849407. doi:10.1042/bj2740813. - Sparkes RS, Klisak I, Miller WL. Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25. DNA and Cell Biology. June 1991, 10 (5): 359–65. PMID 1863359. doi:10.1089/dna.1991.10.359.
- Coghlan VM, Vickery LE. Site-specific mutations in human ferredoxin that affect binding to ferredoxin reductase and cytochrome P450scc. The Journal of Biological Chemistry. October 1991, 266 (28): 18606–12. PMID 1917982.
- Matteson KJ, Chung BC, Urdea MS, Miller WL. Study of cholesterol side-chain cleavage (20,22 desmolase) deficiency causing congenital lipoid adrenal hyperplasia using bovine-sequence P450scc oligodeoxyribonucleotide probes. Endocrinology. April 1986, 118 (4): 1296–305. PMID 2419119. doi:10.1210/endo-118-4-1296.
- Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL. Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta. Proceedings of the National Academy of Sciences of the United States of America. December 1986, 83 (23): 8962–6. PMC 387054 . PMID 3024157. doi:10.1073/pnas.83.23.8962.
- Morohashi K, Sogawa K, Omura T, Fujii-Kuriyama Y. Gene structure of human cytochrome P-450(SCC), cholesterol desmolase. Journal of Biochemistry. April 1987, 101 (4): 879–87. PMID 3038854.
- Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. January 1994, 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Gharani N, Waterworth DM, Batty S, White D, Gilling-Smith C, Conway GS, McCarthy M, Franks S, Williamson R. Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism. Human Molecular Genetics. March 1997, 6 (3): 397–402. PMID 9147642. doi:10.1093/hmg/6.3.397.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. October 1997, 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Hukkanen J, Mäntylä M, Kangas L, Wirta P, Hakkola J, Paakki P, Evisalmi S, Pelkonen O, Raunio H. Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium. Pharmacology & Toxicology. February 1998, 82 (2): 93–7. PMID 9498238. doi:10.1111/j.1600-0773.1998.tb01404.x.
- Zhou Z, Shackleton CH, Pahwa S, White PC, Speiser PW. Prominent sex steroid metabolism in human lymphocytes. Molecular and Cellular Endocrinology. March 1998, 138 (1–2): 61–9. PMID 9685215. doi:10.1016/S0303-7207(98)00052-5.
