TLR4

TLR4
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 4G8A、​2Z62、​2Z63、​2Z65、​2Z66、​3FXI、​3UL7、​3UL8、​3UL9、​3ULA
识别号
别名	TLR4；, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4
外部ID	OMIM：603030 MGI：96824 HomoloGene：41317 GeneCards：TLR4
为以下药物的标靶
resatorvid
基因位置（人类） 染色体 9号染色体 基因座 9q33.1 起始 117,704,175 bp 终止 117,724,735 bp
基因位置（小鼠） 染色体 小鼠4号染色体 基因座 4 C1|4 34.66 cM 起始 66,745,821 bp 终止 66,848,521 bp
RNA表达模式
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基因本体 分子功能 • lipopolysaccharide immune receptor activity • lipopolysaccharide binding • 血浆蛋白结合 • transmembrane signaling receptor activity 细胞组分 • 细胞质 • 膜 • 细胞质的核周区域 • cell surface • integral component of membrane • 细胞膜 • endosome membrane • intrinsic component of plasma membrane • integral component of plasma membrane • lipopolysaccharide receptor complex • external side of plasma membrane 生物学过程 • positive regulation of MHC class II biosynthetic process • positive regulation of JNK cascade • TRIF-dependent toll-like receptor signaling pathway • cellular response to mechanical stimulus • positive regulation of interleukin-8 production • positive regulation of ERK1 and ERK2 cascade • T-helper 1 type immune response • positive regulation of platelet activation • positive regulation of interleukin-1 production • positive regulation of stress-activated MAPK cascade • positive regulation of NLRP3 inflammasome complex assembly • positive regulation of interleukin-12 production • positive regulation of interferon-alpha production • I-kappaB phosphorylation • positive regulation of nitric-oxide synthase biosynthetic process • positive regulation of B cell proliferation • defense response to bacterium • positive regulation of interleukin-6 production • activation of innate immune response • positive regulation of tumor necrosis factor production • 肿瘤坏死因子产生的负调控 • 先天免疫系统 • negative regulation of interleukin-17 production • I-kappaB kinase/NF-kappaB signaling • positive regulation of interferon-beta production • positive regulation of inflammatory response • toll-like receptor 4 signaling pathway • positive regulation of macrophage cytokine production • positive regulation of interleukin-10 production • immune system process • astrocyte development • intestinal epithelial structure maintenance • positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway • response to lipopolysaccharide • cellular response to lipoteichoic acid • positive regulation of NF-kappaB transcription factor activity • 免疫反应 • negative regulation of interleukin-23 production • regulation of inflammatory response • positive regulation of chemokine production • lipopolysaccharide-mediated signaling pathway • detection of fungus • positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway • negative regulation of interferon-gamma production • response to bacterium • negative regulation of osteoclast differentiation • B cell proliferation involved in immune response • positive regulation of nitric oxide biosynthetic process • negative regulation of interleukin-6 production • positive regulation of interferon-gamma production • nitric oxide production involved in inflammatory response • MyD88-dependent toll-like receptor signaling pathway • regulation of dendritic cell cytokine production • positive regulation of gene expression • negative regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • macrophage activation • detection of lipopolysaccharide • cellular response to lipopolysaccharide • positive regulation of lymphocyte proliferation • positive regulation of transcription by RNA polymerase II • MyD88-independent toll-like receptor signaling pathway • 信号转导 • inflammatory response • defense response to Gram-negative bacterium • toll-like receptor signaling pathway • 程序性坏死 • apoptotic signaling pathway • negative regulation of MyD88-independent toll-like receptor signaling pathway Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	7099	21898
Ensembl	ENSG00000136869	ENSMUSG00000039005
UniProt	O00206	Q9QUK6
mRNA​序列	NM_138557 ​NM_003266 ​NM_138554 ​NM_138556	NM_021297
蛋白序列	NP_003257 ​NP_612564 ​NP_612567	NP_067272
基因位置​（UCSC）	Chr 9: 117.7 – 117.72 Mb	Chr 4: 66.75 – 66.85 Mb
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维基数据
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Toll样受体4（英语：Toll-like receptor 4）是由人类基因 TLR4 编码的蛋白质，是一种膜蛋白质，也被称为CD284（分化簇284，cluster of differentiation 284），是模式识别受体中Toll样受体（TLR）家族的成员，可结合其配体脂多糖（LPS）激活NF-κB信号通路，在先天免疫系统中起到重要作用。

外部链接

• 医学主题词表（MeSH）：Toll-Like+Receptor+4
• PDB中UniProt可用的所有结构信息之概述：O00206 (Toll-like receptor 4) 在PDBe-KB。