CD18
整联蛋白β-2（英语：Integrin beta-2，CD18）是一个由人类基因 ITGB2 编码的蛋白质，是整联蛋白的一种β亚基。
能与下列四种整联蛋白α亚基搭配形成四种整联蛋白：
- 淋巴细胞功能性抗原1，LFA-1 (搭配 CD11a)
- 巨噬细胞抗原的1 (搭配 CD11b)
- 整联蛋白αXβ2 (搭配 CD11c)
- 整联蛋白αDβ2 (搭配 CD11d)
相互作用
[编辑]CD18已经与下列蛋白质进行交互作用 ：
参考文献
[编辑]- ^ 與CD18相關的疾病；在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000160255 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000000290 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. The Journal of Biological Chemistry. October 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200.
- ^ Liliental J, Chang DD. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379.
- ^ Kotovuori A, Pessa-Morikawa T, Kotovuori P, Nortamo P, Gahmberg CG. ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity. Journal of Immunology. June 1999, 162 (11): 6613–20. PMID 10352278.
- ^ Lu C, Takagi J, Springer TA. Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state. The Journal of Biological Chemistry. May 2001, 276 (18): 14642–8. PMID 11279101. doi:10.1074/jbc.M100600200.
- ^ Huang C, Springer TA. A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1). The Journal of Biological Chemistry. August 1995, 270 (32): 19008–16. PMID 7642561. doi:10.1074/jbc.270.32.19008.
- ^ Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. The Journal of Biological Chemistry. October 1998, 273 (42): 27459–66. PMID 9765275. doi:10.1074/jbc.273.42.27459.
- ^ Geiger C, Nagel W, Boehm T, van Kooyk Y, Figdor CG, Kremmer E, Hogg N, Zeitlmann L, Dierks H, Weber KS, Kolanus W. Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1. The EMBO Journal. June 2000, 19 (11): 2525–36. PMC 212768
. PMID 10835351. doi:10.1093/emboj/19.11.2525.
延伸阅读
[编辑]外部链接
[编辑]- MeSH（医学主题词）上面的CD18+antigen
- ITGB2 信息的链接在 单元的移徙网关
- Human ITGB2 genome location and ITGB2 gene details page in the UCSC Genome Browser.