SOX9

SOX9
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4EUW
识别号
别名	SOX9；, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9, SRY-box transcription factor 9
外部ID	OMIM：608160 MGI：98371 HomoloGene：294 GeneCards：SOX9
基因位置（人类）
染色体	17号染色体
终止	72,126,416 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	112,678,586 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• DNA结合转录因子活性; • DNA-binding transcription activator activity, RNA polymerase II-specific; • core promoter sequence-specific DNA binding; • 蛋白激酶活性; • protein kinase A catalytic subunit binding; • beta-catenin binding; • pre-mRNA intronic binding; • chromatin binding; • 血浆蛋白结合; • DNA结合; • sequence-specific DNA binding; • transcription cis-regulatory region binding; • bHLH transcription factor binding; • 核心启动子近端区域序列特异性DNA结合; • protein heterodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II cis-regulatory region sequence-specific DNA binding;
细胞组分	• 细胞核; • 转录调节复合物; • 核质; • 大分子复合体;
生物学过程	• 骨骼系统的发生; • cellular response to retinoic acid; • bronchus cartilage development; • positive regulation of protein phosphorylation; • heart valve development; • limb bud formation; • positive regulation of protein catabolic process; • regulation of transcription by RNA polymerase II; • ureter morphogenesis; • negative regulation of immune system process; • chondrocyte development; • positive regulation of cell proliferation involved in heart morphogenesis; • oligodendrocyte differentiation; • chondrocyte hypertrophy; • prostate gland development; • lung smooth muscle development; • 乳腺发育; • negative regulation of ossification; • negative regulation of photoreceptor cell differentiation; • cellular response to mechanical stimulus; • intrahepatic bile duct development; • regulation of cell adhesion; • negative regulation of chondrocyte differentiation; • positive regulation of mesenchymal cell proliferation; • astrocyte fate commitment; • positive regulation of chondrocyte differentiation; • 精子发生; • prostate gland morphogenesis; • negative regulation of epithelial cell proliferation; • lung epithelial cell differentiation; • chondrocyte differentiation involved in endochondral bone morphogenesis; • negative regulation of canonical Wnt signaling pathway; • endocrine pancreas development; • negative regulation of cell population proliferation; • regulation of apoptotic process; • cellular response to transforming growth factor beta stimulus; • negative regulation of mesenchymal cell apoptotic process; • 染色体重建; • negative regulation of myoblast differentiation; • positive regulation of branching involved in ureteric bud morphogenesis; • cell fate commitment; • regulation of transcription, DNA-templated; • epidermal growth factor receptor signaling pathway; • 成骨作用; • regulation of cell proliferation involved in tissue homeostasis; • ureter smooth muscle cell differentiation; • ERK1 and ERK2 cascade; • notochord development; • positive regulation of epithelial cell migration; • Sertoli cell differentiation; • male sex determination; • negative regulation of gene expression; • transcription, DNA-templated; • metanephric nephron tubule formation; • positive regulation of transcription, DNA-templated; • 心脏发育; • regulation of branching involved in lung morphogenesis; • ureter urothelium development; • branching involved in ureteric bud morphogenesis; • 软骨生成; • Harderian gland development; • positive regulation of kidney development; • central nervous system development; • heart valve formation; • positive regulation of cartilage development; • tissue homeostasis; • metanephric tubule development; • negative regulation of biomineral tissue development; • endochondral bone morphogenesis; • trachea cartilage development; • male germ-line sex determination; • 泪腺的发生; • Notch信号通路; • hair follicle development; • 细胞分化; • 输尿管的发生; • regulation of cell cycle process; • male gonad development; • positive regulation of epithelial cell proliferation; • cell fate specification; • intestinal epithelial structure maintenance; • positive regulation of extracellular matrix assembly; • extracellular matrix organization; • negative regulation of apoptotic process; • negative regulation of transcription by RNA polymerase II; • Sertoli cell development; • positive regulation of mesenchymal stem cell differentiation; • retina development in camera-type eye; • cellular response to interleukin-1; • 上皮-间充质转换; • homeostasis of number of cells within a tissue; • negative regulation of transcription, DNA-templated; • cAMP-mediated signaling; • cartilage condensation; • positive regulation of male gonad development; • nucleosome assembly; • negative regulation of bone mineralization; • morphogenesis of a branching epithelium; • neural crest cell development; • Akt/PKB信号通路; • somatic stem cell population maintenance; • otic vesicle formation; • otic vesicle development; • endocardial cushion morphogenesis; • cellular response to epidermal growth factor stimulus; • positive regulation of epithelial cell differentiation; • renal vesicle induction; • positive regulation of gene expression; • regulation of epithelial cell proliferation involved in lung morphogenesis; • regulation of cell population proliferation; • heart valve morphogenesis; • 细胞骨架组织; • cochlea morphogenesis; • positive regulation of cell population proliferation; • epithelial cell proliferation involved in prostatic bud elongation; • retinal rod cell differentiation; • protein localization to nucleus; • regulation of cell differentiation; • positive regulation of phosphatidylinositol 3-kinase signaling; • cellular response to heparin; • negative regulation of epithelial cell differentiation; • epithelial tube branching involved in lung morphogenesis; • 信号转导; • positive regulation of transcription by RNA polymerase II; • negative regulation of pri-miRNA transcription by RNA polymerase II; • chondrocyte differentiation; • neural crest cell fate specification; • cellular response to BMP stimulus; • cell-cell adhesion; • transcription initiation from RNA polymerase II promoter; • protein-containing complex assembly; • anterior head development; • morphogenesis of an epithelium; • aortic valve morphogenesis; • 基因调节;
	Sources:Amigo / QuickGO
直系同源
	6662
	20682
	ENSG00000125398
	ENSMUSG00000000567
	P48436
	Q04887
	NM_000346
	NM_011448
	NP_000337
	NP_035578
	维基数据
查看/编辑人类	查看/编辑小鼠

SOX9（英语：Transcription factor SOX-9）是一种转录因子，由人类基因Sox9编码，是塞尔托利氏细胞等细胞的标志物^[5]^[6]。

相互作用

SOX9可与类固醇生成因子1、MED12^[7]和MAF^[8]发生相互作用。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000125398 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000000567 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tommerup N, Schempp W, Meinecke P, Pedersen S, Bolund L, Brandt C, et al. Assignment of an autosomal sex reversal locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3-q25.1. Nature Genetics. June 1993, 4 (2): 170–4. PMID 8348155. S2CID 12263655. doi:10.1038/ng0693-170.
^ Entrez Gene: SOX9 SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal). [2021-06-01]. （原始内容存档于2010-03-07）.
^ Zhou R, Bonneaud N, Yuan CX, de Santa Barbara P, Boizet B, Schomber T, et al. SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Research. July 2002, 30 (14): 3245–52. PMC 135763 . PMID 12136106. doi:10.1093/nar/gkf443.
^ Huang W, Lu N, Eberspaecher H, De Crombrugghe B. A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene. The Journal of Biological Chemistry. December 2002, 277 (52): 50668–75. PMID 12381733. doi:10.1074/jbc.M206544200 .

外部链接

医学主题词表（MeSH）：SOX9+protein,+human
Template:UCSC genome browser
Template:UCSC gene details
PDB中UniProt可用的所有结构信息之概述：P48436 (Human Transcription factor SOX-9) 在PDBe-KB（英语：PDBe-KB）。
PDB中UniProt可用的所有结构信息之概述：Q04887 (Mouse Transcription factor SOX-9) 在PDBe-KB（英语：PDBe-KB）。

SOX9引用了美国国家医学图书馆提供的数据，这些数据属于公共领域。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000125398 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000000567 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8348155-5] Tommerup N, Schempp W, Meinecke P, Pedersen S, Bolund L, Brandt C, et al. Assignment of an autosomal sex reversal locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3-q25.1. Nature Genetics. June 1993, 4 (2): 170–4. PMID 8348155. S2CID 12263655. doi:10.1038/ng0693-170.

[entrez-6] Entrez Gene: SOX9 SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal). [2021-06-01]. （原始内容存档于2010-03-07）.

[pmid12136106-7] Zhou R, Bonneaud N, Yuan CX, de Santa Barbara P, Boizet B, Schomber T, et al. SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Research. July 2002, 30 (14): 3245–52. PMC 135763 . PMID 12136106. doi:10.1093/nar/gkf443.

[pmid12381733-8] Huang W, Lu N, Eberspaecher H, De Crombrugghe B. A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene. The Journal of Biological Chemistry. December 2002, 277 (52): 50668–75. PMID 12381733. doi:10.1074/jbc.M206544200 .

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