胱天蛋白酶7
胱天蛋白酶7（英语：Caspase 7）是人类中由CASP7基因编码的一种酶。该酶是一种参与细胞凋亡的半胱氨酸蛋白酶。几乎所有可获得完整基因组数据的哺乳动物中都已鉴定出CASP7直向同源物。[7]鸟类、蜥蜴、滑体动物和真骨类中也存在独特的直系同源物。
作用
[编辑]胱天蛋白酶7是胱天蛋白酶家族的成员，已被证明是细胞凋亡的执行蛋白。胱天蛋白酶的连续激活在细胞凋亡的执行阶段发挥着核心作用。胱天蛋白酶作为无活性酶原存在，由上游的胱天蛋白酶（胱天蛋白酶8、9）在保守的天冬氨酸残基处经历蛋白水解加工，产生一大一小两个亚基，然后二聚化形成异四聚体形式的活性酶。该酶的前体被胱天蛋白酶3、10和9裂解。该酶在细胞死亡刺激下被激活并诱导细胞凋亡。该基因的选择性剪接产生四种转录变体，编码三种不同的亚型。[8]
相互作用
[编辑]胱天蛋白酶7已被证明可以与以下物质相互作用：
参见
[编辑]参考文献
[编辑]- ^ 與胱天蛋白酶7相關的疾病；在維基數據上查看/編輯參考.
- ^ 對Caspase 7起作用的藥物；在維基數據上查看/編輯參考.
- ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000165806 - Ensembl, May 2017
- ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000025076 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ OrthoMaM phylogenetic marker: CASP7 coding sequence. [2009-12-20]. （原始内容存档于2016-03-04）.
- ^ Entrez Gene: CASP7 caspase 7, apoptosis-related cysteine peptidase.
- ^ Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. Apr 2002, 277 (16): 13430–7. PMID 11832478. doi:10.1074/jbc.M108029200
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- ^ Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri ES. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. Dec 1996, 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. PMC 26159 . PMID 8962078. doi:10.1073/pnas.93.25.14486 .
- ^ Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. Dec 1998, 58 (23): 5315–20. PMID 9850056.
- ^ Shin S, Sung BJ, Cho YS, Kim HJ, Ha NC, Hwang JI, Chung CW, Jung YK, Oh BH. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry. Jan 2001, 40 (4): 1117–23. PMID 11170436. doi:10.1021/bi001603q.
- ^ Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS. Structural basis for the inhibition of caspase-3 by XIAP. Cell. Mar 2001, 104 (5): 791–800. PMID 11257232. S2CID 17915093. doi:10.1016/S0092-8674(01)00274-4 .
- ^ Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. Dec 1997, 16 (23): 6914–25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.
- ^ Deveraux QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. Jul 1997, 388 (6639): 300–4. Bibcode:1997Natur.388..300D. PMID 9230442. S2CID 4395885. doi:10.1038/40901 .
- ^ Suzuki Y, Nakabayashi Y, Nakata K, Reed JC, Takahashi R. X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes. J. Biol. Chem. Jul 2001, 276 (29): 27058–63. PMID 11359776. doi:10.1074/jbc.M102415200 .
拓展阅读
[编辑]- Cohen GM. Caspases: the executioners of apoptosis. Biochem. J. 1997, 326 (Pt 1): 1–16. PMC 1218630 . PMID 9337844. doi:10.1042/bj3260001.
