BNN-20

BNN-20
臨床資料
其他名稱	BNN20; 17β-Spiro-(androst-5-en-17,2'-oxiran)-3β-ol
識別資訊
	IUPAC命名法 (3S,8R,9S,10R,13S,14S,17S)-10,13-Dimethylspiro[1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,2'-oxirane]-3-ol; ;
CAS號	847-75-6
PubChem CID	44542342;
ChemSpider	24661247;
UNII	5WM22TG224;
ChEMBL	ChEMBL1076355;
化學資訊
化學式	C20H30O2
摩爾質量	302.46 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]45CO5)C)O;
	InChI InChI=1S/C20H30O2/c1-18-8-5-14(21)11-13(18)3-4-15-16(18)6-9-19(2)17(15)7-10-20(19)12-22-20/h3,14-17,21H,4-12H2,1-2H3/t14-,15+,16-,17-,18-,19-,20+/m0/s1; Key:LKDLANDMNIFZOI-IJMQKCTASA-N;

BNN-20（化學名：17β-螺-(雄甾-5-烯-17,2'-環氧)-3β-醇，英語：17β-spiro-(androst-5-en-17,2'-oxiran)-3β-ol）是一種有機化合物，化學式C
20H
30O
2，是一種人工合成的神經甾體。^[1]^[2]

參考文獻

^ Calogeropoulou T, Avlonitis N, Minas V, Alexi X, Pantzou A, Charalampopoulos I, Zervou M, Vergou V, Katsanou ES, Lazaridis I, Alexis MN, Gravanis A. Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity. J. Med. Chem. 2009, 52 (21): 6569–87. PMID 19845386. doi:10.1021/jm900468p.
^ Botsakis K, Mourtzi T, Panagiotakopoulou V, Vreka M, Stathopoulos GT, Pediaditakis I, Charalampopoulos I, Gravanis A, Delis F, Antoniou K, Zisimopoulos D, Georgiou CD, Panagopoulos NT, Matsokis N, Angelatou F. BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the "weaver" mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor. Neuropharmacology. 2017, 121: 140–157. PMID 28461162. S2CID 5071762. doi:10.1016/j.neuropharm.2017.04.043.