CRADD

CRADD
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	2O71、2OF5、3CRD
識別號
別名	CRADD；, MRT34, RAIDD, CASP2 and RIPK1 domain containing adaptor with death domain
外部ID	OMIM：603454 MGI：1336168 HomoloGene：2821 GeneCards：CRADD
相關疾病
	阿茲海默症、syndromic intellectual disability
基因位置（人類）
染色體	12號染色體
終止	93,894,840 bp
基因位置（小鼠）
染色體	小鼠10號染色體
終止	95,159,995 bp
基因本體
分子功能	• protein-macromolecule adaptor activity; • 血漿蛋白結合; • 蛋白酶結合; • death domain binding;
細胞組分	• 細胞質; • 細胞核; • 細胞質基質;
生物學過程	• cellular response to mechanical stimulus; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • positive regulation of apoptotic signaling pathway; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • extrinsic apoptotic signaling pathway via death domain receptors; • 信號轉導; • 細胞凋亡; • regulation of apoptotic process; • positive regulation of apoptotic process; • apoptotic signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	8738
	12905
	ENSG00000169372
	ENSMUSG00000045867
	P78560; Q8IY43
	O88843
	NM_003805; NM_001320099; NM_001320100; NM_001320101; NM_001330126
	NM_009950; NM_001330138; NM_001330141; NM_001330175
NP_001307028; NP_001307029; NP_001307030; NP_001317055; NP_003796;
	NP_001307028.1
	NP_001317067; NP_001317070; NP_001317104; NP_034080
	維基數據
檢視/編輯人類	檢視/編輯小鼠

含有死亡結構域的蛋白質CRADD（英語：Death domain-containing protein CRADD）是人類中由CRADD基因編碼的蛋白質。^[6]^[7]^[8]

功能

該基因編碼的蛋白質是含有死亡結構域（CARD/DD）的蛋白質，已被證明可誘導細胞凋亡。通過其CARD結構域（英語：CARD (domain)），該蛋白與胱天蛋白酶2/ICH1相互作用，從而將胱天蛋白酶2/ICH1募集到細胞死亡信號轉導複合物中，該複合物包括腫瘤壞死因子受體1（英語：Tumor necrosis factor receptor 1）（TNFR1A）、RIPK1（英語：RIPK1）/RIP激酶和許多其他含有CARD結構域的蛋白。^[8]

相互作用

CRADD已被證明與RIPK1（英語：RIPK1）^[6]^[7]和胱天蛋白酶2^[6]^[9]^[10]相互作用。

參考資料

^ 與CRADD相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000169372 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000045867 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^6.0 ^6.1 ^6.2 Duan H, Dixit VM. RAIDD is a new 'death' adaptor molecule (PDF). Nature. January 1997, 385 (6611): 86–9. Bibcode:1997Natur.385...86D. PMID 8985253. S2CID 4317538. doi:10.1038/385086a0. hdl:2027.42/62739 .
^ ^7.0 ^7.1 Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. March 1997, 57 (4): 615–9. PMID 9044836.
^ ^8.0 ^8.1 Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain. [2024-01-20]. （原始內容存檔於2010-12-05）.
^ Tinel A, Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. May 2004, 304 (5672): 843–6. Bibcode:2004Sci...304..843T. PMID 15073321. S2CID 6583298. doi:10.1126/science.1095432.
^ Droin N, Beauchemin M, Solary E, Bertrand R. Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. Cancer Res. December 2000, 60 (24): 7039–47. PMID 11156409.

外部連結

Human CRADD genome location and CRADD gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.

延伸閱讀

Lennon G, Auffray C, Polymeropoulos M, Soares MB. The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics. 1996, 33 (1): 151–2. PMID 8617505. doi:10.1006/geno.1996.0177 .
Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M. Generation and analysis of 280,000 human expressed sequence tags. Genome Res. 1996, 6 (9): 807–28. PMID 8889549. doi:10.1101/gr.6.9.807 .
Chou JJ, Matsuo H, Duan H, Wagner G. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell. 1998, 94 (2): 171–80. PMID 9695946. S2CID 16499945. doi:10.1016/S0092-8674(00)81417-8 .
Horvat S, Medrano JF. A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region. Genomics. 1998, 54 (1): 159–64. PMID 9806843. doi:10.1006/geno.1998.5540.
Shearwin-Whyatt LM, Harvey NL, Kumar S. Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. Cell Death Differ. 2000, 7 (2): 155–65. PMID 10713730. doi:10.1038/sj.cdd.4400632 .
Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L. Activation of the NF-kappaB pathway by caspase 8 and its homologs. Oncogene. 2000, 19 (39): 4451–60. PMID 11002417. doi:10.1038/sj.onc.1203812 .
Droin N, Beauchemin M, Solary E, Bertrand R. Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. Cancer Res. 2000, 60 (24): 7039–47. PMID 11156409.
Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. 2002, 277 (16): 13430–7. PMID 11832478. doi:10.1074/jbc.M108029200 .
Tinel A, Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. 2004, 304 (5672): 843–6. Bibcode:2004Sci...304..843T. PMID 15073321. S2CID 6583298. doi:10.1126/science.1095432.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005, 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209.
Park HH, Wu H. Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly. J. Mol. Biol. 2006, 357 (2): 358–64. PMC 2902980 . PMID 16434054. doi:10.1016/j.jmb.2005.12.082.
Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene. 2006, 25 (41): 5683–92. PMID 16652156. doi:10.1038/sj.onc.1209569 .
Park HH, Wu H. Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD. Acta Crystallographica Section F. 2007, 63 (Pt 3): 229–32. PMC 2330181 . PMID 17329820. doi:10.1107/S1744309107007889.

[1] 與CRADD相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000169372 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000045867 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8985253-6] 6.0 ^6.1 ^6.2 Duan H, Dixit VM. RAIDD is a new 'death' adaptor molecule (PDF). Nature. January 1997, 385 (6611): 86–9. Bibcode:1997Natur.385...86D. PMID 8985253. S2CID 4317538. doi:10.1038/385086a0. hdl:2027.42/62739 .

[pmid9044836-7] 7.0 ^7.1 Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. March 1997, 57 (4): 615–9. PMID 9044836.

[entrez-8] 8.0 ^8.1 Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain. [2024-01-20]. （原始內容存檔於2010-12-05）.

[pmid15073321-9] Tinel A, Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. May 2004, 304 (5672): 843–6. Bibcode:2004Sci...304..843T. PMID 15073321. S2CID 6583298. doi:10.1126/science.1095432.

[pmid11156409-10] Droin N, Beauchemin M, Solary E, Bertrand R. Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. Cancer Res. December 2000, 60 (24): 7039–47. PMID 11156409.

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