Spo11

Spo11
识别号
别名	SPO11；, CT35, SPATA43, TOPVIA, initiator of meiotic double stranded breaks, SPO11 initiator of meiotic double stranded breaks, Meiotic recombination, Spo11, Meiotic_Spo11, IPR013048, Spo11, TOPOVIA
外部ID	OMIM：605114 MGI：1349669 HomoloGene：6059 GeneCards：SPO11
基因位置（人类）
染色体	20号染色体
终止	57,343,994 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	172,835,369 bp
基因本体
分子功能	• 金属离子结合; • 催化活性; • 水解酶活性; • ATP结合; • 血浆蛋白结合; • isomerase activity; • DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; • endodeoxyribonuclease activity, producing 3'-phosphomonoesters; • DNA结合;
细胞组分	• 染色体; • 端粒; • 细胞核; • nuclear chromosome;
生物学过程	• protein localization to chromosome; • 雌配子发生; • meiotic telomere clustering; • male meiosis I; • DNA代谢过程; • DNA catabolic process, endonucleolytic; • 卵子发生; • homologous chromosome pairing at meiosis; • 减数分裂; • synaptonemal complex assembly; • 精子发生; • spermatid development; • ovarian follicle development; • meiotic DNA double-strand break processing; • meiotic DNA double-strand break formation; • reciprocal meiotic recombination; • double-strand break repair involved in meiotic recombination;
	Sources:Amigo / QuickGO
直系同源
	23626
	26972
	ENSG00000054796
	ENSMUSG00000005883
	Q9Y5K1; Q5TCH6
	Q9WTK8
	NM_012444; NM_198265
	NM_001083959; NM_001083960; NM_012046; NM_001305434
	NP_036576; NP_937998
	NP_001077428; NP_001077429; NP_001292363; NP_036176
	维基数据
查看/编辑人类	查看/编辑小鼠

Spo11是人类基因spo11 编码的蛋白质，在真核生物中广泛存在，与古菌基因TopVIA为直系同源体，负责减数第一次分裂前期遗传重组中DNA的双链断裂的形成^[5]^[6]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000054796 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000005883 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vrielynck N, Chambon A, Vezon D, Pereira L, Chelysheva L, De Muyt A, et al. A DNA topoisomerase VI-like complex initiates meiotic recombination. Science. February 2016, 351 (6276): 939–43 [2020-08-29]. Bibcode:2016Sci...351..939V. PMID 26917763. S2CID 206643600. doi:10.1126/science.aad5196. （原始内容存档于2020-07-11）.
^ Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. February 2016, 351 (6276): 943–9 [2020-08-29]. Bibcode:2016Sci...351..943R. PMID 26917764. S2CID 9445593. doi:10.1126/science.aad5309. （原始内容存档于2020-07-11）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000054796 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000005883 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Vrielynck N, Chambon A, Vezon D, Pereira L, Chelysheva L, De Muyt A, et al. A DNA topoisomerase VI-like complex initiates meiotic recombination. Science. February 2016, 351 (6276): 939–43 [2020-08-29]. Bibcode:2016Sci...351..939V. PMID 26917763. S2CID 206643600. doi:10.1126/science.aad5196. （原始内容存档于2020-07-11）.

[6] Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. February 2016, 351 (6276): 943–9 [2020-08-29]. Bibcode:2016Sci...351..943R. PMID 26917764. S2CID 9445593. doi:10.1126/science.aad5309. （原始内容存档于2020-07-11）.

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