PRE-084

PRE-084
临床资料
ATC码	未分配;
识别信息
	IUPAC命名法 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate; ;
CAS号	138847-85-5
PubChem CID	126402;
IUPHAR/BPS	6678;
ChemSpider	112335 ;
UNII	74BW8WG2MQ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID40160819 ;
化学信息
化学式	C19H27NO3
摩尔质量	317.43 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES c1ccccc1C2(CCCCC2)C(=O)OCCN3CCOCC3;
	InChI InChI=1S/C19H27NO3/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17/h1,3-4,7-8H,2,5-6,9-16H2 ; Key:RQHKZUBCUZVZEF-UHFFFAOYSA-N ;

PRE-084是一种含氮有机化合物，化学式C
19H
27NO
3，能作为σ受体特别是σ₁的选择性激动剂，在动物实验中有益智药、抗抑郁药和止咳药作用^[1]^[2]^[3]^[4]^[5]。

参考文献

^ Maurice T, Su TP, Parish DW, Nabeshima T, Privat A. PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice. Pharmacology Biochemistry and Behavior. December 1994, 49 (4): 859–69. PMID 7886099. S2CID 54306053. doi:10.1016/0091-3057(94)90235-6.
^ Maurice T. Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats. European Journal of Pharmacology. November 2001, 431 (2): 223–7. PMID 11728429. doi:10.1016/S0014-2999(01)01436-4.
^ Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL. Antitussive activity of sigma-1 receptor agonists in the guinea-pig. British Journal of Pharmacology. January 2004, 141 (2): 233–40. PMC 1574192 . PMID 14691051. doi:10.1038/sj.bjp.0705605.
^ Skuza G, Rogóz Z. Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice. Pharmacological Reports. 2009, 61 (6): 1179–83. PMID 20081254. S2CID 96025873. doi:10.1016/S1734-1140(09)70181-1.
^ Hiranita T, Soto PL, Tanda G, Katz JL. Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine. The Journal of Pharmacology and Experimental Therapeutics. February 2010, 332 (2): 515–24. PMC 2812106 . PMID 19892920. doi:10.1124/jpet.109.159236.