ELB-139

ELB-139
识别信息
	IUPAC命名法 1-(4-Chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-one; ;
CAS号	188116-08-7
PubChem CID	11277418;
ChemSpider	9452418;
UNII	BKP2A5554F;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID40877536 ;
化学信息
化学式	C14H16ClN3O
摩尔质量	277.75 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES Clc3ccc(cc3)N1CC(=NC1=O)N2CCCCC2;
	InChI InChI=1S/C14H16ClN3O/c15-11-4-6-12(7-5-11)18-10-13(16-14(18)19)17-8-2-1-3-9-17/h4-7H,1-3,8-10H2; Key:YGXIELIREXEJQN-UHFFFAOYSA-N;

ELB-139或LS-191,811是一种含氮有机氯化合物，化学式C
14H
16ClN
3O，能作为非苯二氮䓬类抗焦虑药^[1]^[2]。

它可由1-(4-氯苯基)-2,4-咪唑烷二酮和哌啶在吡啶盐酸盐存在下反应制得。^[3]

参考文献

^ Langen B, Egerland U, Bernöster K, Dost R, Unverferth K, Rundfeldt C. Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor. The Journal of Pharmacology and Experimental Therapeutics. August 2005, 314 (2): 717–24. PMID 15860576. S2CID 21967108. doi:10.1124/jpet.105.084681.
^ Atack JR. The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics. Expert Opinion on Investigational Drugs. May 2005, 14 (5): 601–18. PMID 15926867. S2CID 22793644. doi:10.1517/13543784.14.5.601.
^ Grunwald, Christian; et al. Synthesis, Pharmacology, and Structure-Activity Relationships of Novel Imidazolones and Pyrrolones as Modulators of GABAA Receptors. Journal of Medicinal Chemistry (2006), 49(6), 1855-1866. doi:10.1021/jm0509400.