19-去甲孕酮
外观
临床资料 | |
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其他名称 | 10-Norprogesterone; 19-Norpregn-4-ene-3,20-dione; 17β-Acetylestr-4-en-3-one |
给药途径 | 不经肠 |
药物类别 | Progestin; Progestogen; Mineralocorticoid |
识别信息 | |
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CAS号 | 472-54-8 |
PubChem CID | |
ChemSpider | |
CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C20H28O2 |
摩尔质量 | 300.435 g/mol |
3D模型(JSmol) | |
熔点 | 144至145 °C(291至293 °F) |
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19-去甲孕酮(英语:19-Norprogesterone)也叫做19-去甲孕甾-4-烯-3,20-二酮(英语:19-norpregn-4-ene-3,20-dione)是性激素孕酮的结构类似物,只少了19号C原子的甲基。19-去甲孕酮首次合成于1944年,但1944年的产物带有多种立体异构物[1][2][3][4]。
参考文献
[编辑]- ^ Ehrenstein, Maximilian. INVESTIGATIONS ON STEROIDS. VIII. LOWER HOMOLOGS OF HORMONES OF THE PREGNANE SERIES: 10-NOR-11-DESOXY-CORTICOSTERONE ACETATE AND 10-NORPROGESTERONE1. The Journal of Organic Chemistry. 1944, 09 (5): 435–456. ISSN 0022-3263. doi:10.1021/jo01187a009.
- ^ Allen WM, Ehrenstein M. 10-NOR-PROGESTERONE, A PHYSIOLOGICALLY ACTIVE LOWER HOMOLOG OF PROGESTERONE. Science. 1944, 100 (2594): 251–2. PMID 17738394. doi:10.1126/science.100.2594.251.
- ^ Miramontes, L.; Rosenkranz, G.; Djerassi, Carl. STEROIDS. XXII. THE SYNTHESIS OF 19-NORPROGESTERONE. Journal of the American Chemical Society. 1951, 73 (7): 3540–3541. ISSN 0002-7863. doi:10.1021/ja01151a547.
- ^ Djerassi, Carl; Miramontes, L.; Rosenkranz, G. Steroids. XLVIII.119-Norprogesterone, a Potent Progestational Hormone. Journal of the American Chemical Society. 1953, 75 (18): 4440–4442. ISSN 0002-7863. doi:10.1021/ja01114a013.