链蠕孢素

链蠕孢素
	IUPAC名; 1,4,5,7-tetrahydroxy-2-methylanthracene-9,10-dione
别名	4-羟基大黄素
识别
CAS号	476-46-0
PubChem	10150
ChemSpider	9744
SMILES	CC1=CC(=C2C(=C1O)C(=O)C3=C(C2=O)C(=CC(=C3)O)O)O;
性质
化学式	C15H10O6
摩尔质量	286.24 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

链蠕孢素是一种具有蒽醌结构的有机物^[1]^[2]，化学式为C
15H
10O
6，它是一种天然产物。

它存在于一些植物中，如核腔菌属^[3]、翼核木属^[4]、曲霉属^[5]^[6]和篮状菌属^[7]^[8]的物种。

参考文献

^ Yang, Wen-Chin; Shen, Ming-Yi; Jang, Yu-Song; Chen, Zeng-Weng; Chang, Cicero. Catenarin, an anthraquinone compound, inhibits CXCR4 and CCR5 pathways to protect against type 1 diabetes in NOD mice (72.1). The Journal of Immunology. 2012-05-01, 188 (1_Supplement): 72.1. ISSN 0022-1767. doi:10.4049/jimmunol.188.Supp.72.1.
^ Martorell, Miquel; Castro, Natalia; Victoriano, Montserrat; Capó, Xavier; Tejada, Silvia; Vitalini, Sara; Pezzani, Raffaele; Sureda, Antoni. An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes. Evidence-based Complementary and Alternative Medicine : ECAM. 2021-09-20, 2021: 3313419. PMC 8476274 . PMID 34589130. doi:10.1155/2021/3313419  （英语）.
^ Engström, Karin; Brishammar, Sture; Svensson, Christer; Bengtsson, Maria; Andersson, Rolf. Anthraquinones from some Drechslera species and Bipolaris sorokiniana. Mycological Research. 1993-03-01, 97 (3): 381–384. ISSN 0953-7562. doi:10.1016/S0953-7562(09)81142-8.
^ Lin, L. C.; Chou, C. J.; Kuo, Y. C. Cytotoxic principles from Ventilago leiocarpa. Journal of Natural Products. May 2001, 64 (5): 674–676. ISSN 0163-3864. PMID 11374975. doi:10.1021/np000569d.
^ Arai, Kunizo; Aoki, Yasuji; Yamamoto, Yuzuru. Asperinines A and B, Dimeric Tetrahydroanthracene Derivatives from Aspergillus ruber. Chemical & Pharmaceutical Bulletin. 1989, 37 (3): 621–625. doi:10.1248/cpb.37.621.
^ Du, Lin; Zhu, Tianjiao; Liu, Hongbing; Fang, Yuchun; Zhu, Weiming; Gu, Qianqun. Cytotoxic Polyketides from a Marine-derived Fungus Aspergillus glaucus. Journal of Natural Products. 2008-12-01, 71 (11): 1837–1842. ISSN 0163-3864. PMID 18986198. doi:10.1021/np800303t.
^ Bu'Lock, J. D.; Smith, J. R. Modified anthraquinones from Penicillium islandicum. Journal of the Chemical Society C: Organic. 1968-01-01: 1941–1943. ISSN 0022-4952. doi:10.1039/J39680001941 （英语）.
^ van Eijk, G. W. Anthraquinones in the fungus Talaromyces stipitatus. Experientia. 1973-05-01, 29 (5): 522–523. ISSN 0014-4754. PMID 4730274. doi:10.1007/BF01926640 （英语）.

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[1] Yang, Wen-Chin; Shen, Ming-Yi; Jang, Yu-Song; Chen, Zeng-Weng; Chang, Cicero. Catenarin, an anthraquinone compound, inhibits CXCR4 and CCR5 pathways to protect against type 1 diabetes in NOD mice (72.1). The Journal of Immunology. 2012-05-01, 188 (1_Supplement): 72.1. ISSN 0022-1767. doi:10.4049/jimmunol.188.Supp.72.1.

[2] Martorell, Miquel; Castro, Natalia; Victoriano, Montserrat; Capó, Xavier; Tejada, Silvia; Vitalini, Sara; Pezzani, Raffaele; Sureda, Antoni. An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes. Evidence-based Complementary and Alternative Medicine : ECAM. 2021-09-20, 2021: 3313419. PMC 8476274 . PMID 34589130. doi:10.1155/2021/3313419  （英语）.

[3] Engström, Karin; Brishammar, Sture; Svensson, Christer; Bengtsson, Maria; Andersson, Rolf. Anthraquinones from some Drechslera species and Bipolaris sorokiniana. Mycological Research. 1993-03-01, 97 (3): 381–384. ISSN 0953-7562. doi:10.1016/S0953-7562(09)81142-8.

[4] Lin, L. C.; Chou, C. J.; Kuo, Y. C. Cytotoxic principles from Ventilago leiocarpa. Journal of Natural Products. May 2001, 64 (5): 674–676. ISSN 0163-3864. PMID 11374975. doi:10.1021/np000569d.

[5] Arai, Kunizo; Aoki, Yasuji; Yamamoto, Yuzuru. Asperinines A and B, Dimeric Tetrahydroanthracene Derivatives from Aspergillus ruber. Chemical & Pharmaceutical Bulletin. 1989, 37 (3): 621–625. doi:10.1248/cpb.37.621.

[6] Du, Lin; Zhu, Tianjiao; Liu, Hongbing; Fang, Yuchun; Zhu, Weiming; Gu, Qianqun. Cytotoxic Polyketides from a Marine-derived Fungus Aspergillus glaucus. Journal of Natural Products. 2008-12-01, 71 (11): 1837–1842. ISSN 0163-3864. PMID 18986198. doi:10.1021/np800303t.

[7] Bu'Lock, J. D.; Smith, J. R. Modified anthraquinones from Penicillium islandicum. Journal of the Chemical Society C: Organic. 1968-01-01: 1941–1943. ISSN 0022-4952. doi:10.1039/J39680001941 （英语）.

[8] van Eijk, G. W. Anthraquinones in the fungus Talaromyces stipitatus. Experientia. 1973-05-01, 29 (5): 522–523. ISSN 0014-4754. PMID 4730274. doi:10.1007/BF01926640 （英语）.

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