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环戊丙酸雌二醇

维基百科,自由的百科全书
环戊丙酸雌二醇
临床资料
读音/ˌɛstrəˈdl sɪˈpnt/
ES-trə-DY-ohl sih-PY-oh-nate[1]
商品名英语Drug nomenclatureDepo-Estradiol, Depofemin, Estradep, many others
其他名称EC; E2C; Estradiol cipionate; Estradiol cyclopentylpropionate; ECP; Estradiol 17β-cyclopentylpropionate; Estradiol 17β-cyclopentanepropionate
给药途径Intramuscular injection, subcutaneous injection
药物类别Estrogen; Estrogen ester
ATC码
法律规范状态
法律规范
  • 处方药(-only)
药物动力学数据
生物利用度IM: High
血浆蛋白结合率Estradiol: ~98% (to albumin and SHBG)[2][3]
药物代谢Cleavage via esterases in the liver, blood, and tissues
代谢产物Estradiol, cypionic acid, and metabolites of estradiol
生物半衰期IM (aqueous suspension): 8–10 days[4]
作用时间IM (oil): 5 mg ≈ 11–14 days[5]
IM (aqueous suspension): 5 mg ≈ 14–24 days[4]\grave{}
排泄途径Urine
识别信息
  • [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] 3-cyclopentylpropanoate
CAS号313-06-4
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.005.672 编辑维基数据链接
化学信息
化学式C26H36O3
摩尔质量396.57 g·mol−1
3D模型(JSmol英语JSmol
熔点151至152 °C(304至306 °F)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OC(=O)CCC4CCCC4)CCC5=C3C=CC(=C5)O
  • InChI=1S/C26H36O3/c1-26-15-14-21-20-10-8-19(27)16-18(20)7-9-22(21)23(26)11-12-24(26)29-25(28)13-6-17-4-2-3-5-17/h8,10,16-17,21-24,27H,2-7,9,11-15H2,1H3/t21-,22-,23+,24+,26+/m1/s1
  • Key:UOACKFBJUYNSLK-XRKIENNPSA-N

环戊丙酸雌二醇(英语:Estradiol cypionate,缩写EC,商品名有Depo-Estradiol等)是一种有机化合物,化学式C
26
H
36
O
3
,属于一种雌二醇的17β,其复方药环戊丙酸雌二醇/醋酸甲羟孕酮列入世界卫生组织基本药物标准清单

参考文献

[编辑]
  1. ^ Estradiol: Uses, Dosage & Side Effects. Drugs.com. [21 April 2023]. 
  2. ^ Stanczyk FZ, Archer DF, Bhavnani BR. Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment. Contraception. June 2013, 87 (6): 706–727. PMID 23375353. doi:10.1016/j.contraception.2012.12.011. 
  3. ^ Gupta MK, Chia SY. Ovarian Hormones: Structure, Biosynthesis, Function, Mechanism of Action, and Laboratory Diagnosis. Falcone T, Hurd WW (编). Clinical Reproductive Medicine and Surgery. Elsevier Health Sciences. 2007: 22. ISBN 978-0-323-03309-1. ; Arredondo F, Liu JH. Menopause. Falcone T, Hurd WW (编). Clinical Reproductive Medicine and Surgery. Elsevier Health Sciences. 2007: 362,388. ISBN 978-0-323-03309-1. 
  4. ^ 4.0 4.1 Thurman A, Kimble T, Hall P, Schwartz JL, Archer DF. Medroxyprogesterone acetate and estradiol cypionate injectable suspension (Cyclofem) monthly contraceptive injection: steady-state pharmacokinetics. Contraception. June 2013, 87 (6): 738–43. PMID 23265980. doi:10.1016/j.contraception.2012.11.010. 
  5. ^ Oriowo MA, Landgren BM, Stenström B, Diczfalusy E. A comparison of the pharmacokinetic properties of three estradiol esters. Contraception. April 1980, 21 (4): 415–24. PMID 7389356. doi:10.1016/S0010-7824(80)80018-7.