环戊丙酸雌二醇
外观
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临床资料 | |
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读音 | /ˌɛstrəˈdaɪoʊl sɪˈpaɪoʊneɪt/ ES-trə-DY-ohl sih-PY-oh-nate[1] |
商品名 | Depo-Estradiol, Depofemin, Estradep, many others |
其他名称 | EC; E2C; Estradiol cipionate; Estradiol cyclopentylpropionate; ECP; Estradiol 17β-cyclopentylpropionate; Estradiol 17β-cyclopentanepropionate |
给药途径 | Intramuscular injection, subcutaneous injection |
药物类别 | Estrogen; Estrogen ester |
ATC码 | |
法律规范状态 | |
法律规范 |
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药物动力学数据 | |
生物利用度 | IM: High |
血浆蛋白结合率 | Estradiol: ~98% (to albumin and SHBG)[2][3] |
药物代谢 | Cleavage via esterases in the liver, blood, and tissues |
代谢产物 | Estradiol, cypionic acid, and metabolites of estradiol |
生物半衰期 | IM (aqueous suspension): 8–10 days[4] |
作用时间 | IM (oil): 5 mg ≈ 11–14 days[5] IM (aqueous suspension): 5 mg ≈ 14–24 days[4]\grave{} |
排泄途径 | Urine |
识别信息 | |
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CAS号 | 313-06-4 |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.005.672 |
化学信息 | |
化学式 | C26H36O3 |
摩尔质量 | 396.57 g·mol−1 |
3D模型(JSmol) | |
熔点 | 151至152 °C(304至306 °F) |
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环戊丙酸雌二醇(英语:Estradiol cypionate,缩写EC,商品名有Depo-Estradiol等)是一种有机化合物,化学式C
26H
36O
3,属于一种雌二醇的17β酯,其复方药环戊丙酸雌二醇/醋酸甲羟孕酮列入世界卫生组织基本药物标准清单。
参考文献
[编辑]- ^ Estradiol: Uses, Dosage & Side Effects. Drugs.com. [21 April 2023].
- ^ Stanczyk FZ, Archer DF, Bhavnani BR. Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment. Contraception. June 2013, 87 (6): 706–727. PMID 23375353. doi:10.1016/j.contraception.2012.12.011.
- ^ Gupta MK, Chia SY. Ovarian Hormones: Structure, Biosynthesis, Function, Mechanism of Action, and Laboratory Diagnosis. Falcone T, Hurd WW (编). Clinical Reproductive Medicine and Surgery. Elsevier Health Sciences. 2007: 22. ISBN 978-0-323-03309-1.; Arredondo F, Liu JH. Menopause. Falcone T, Hurd WW (编). Clinical Reproductive Medicine and Surgery. Elsevier Health Sciences. 2007: 362,388. ISBN 978-0-323-03309-1.
- ^ 4.0 4.1 Thurman A, Kimble T, Hall P, Schwartz JL, Archer DF. Medroxyprogesterone acetate and estradiol cypionate injectable suspension (Cyclofem) monthly contraceptive injection: steady-state pharmacokinetics. Contraception. June 2013, 87 (6): 738–43. PMID 23265980. doi:10.1016/j.contraception.2012.11.010.
- ^ Oriowo MA, Landgren BM, Stenström B, Diczfalusy E. A comparison of the pharmacokinetic properties of three estradiol esters. Contraception. April 1980, 21 (4): 415–24. PMID 7389356. doi:10.1016/S0010-7824(80)80018-7.