促肾上腺皮质素释放素

促皮质素释放激素
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3EHU、3EHT、1GOE
识别号
别名	CRH；, CRF, CRH1, corticotropin releasing hormone
外部ID	OMIM：122560 MGI：88496 HomoloGene：599 GeneCards：CRH
基因位置（人类）
染色体	8号染色体
终止	66,178,464 bp
基因位置（小鼠）
染色体	小鼠3号染色体
终止	19,749,560 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• hormone activity; • corticotropin-releasing hormone receptor 1 binding; • corticotropin-releasing hormone receptor 2 binding; • 血浆蛋白结合; • neuropeptide hormone activity; • signaling receptor binding; • corticotropin-releasing hormone activity;
细胞组分	• 细胞质; • 细胞本体; • varicosity; • 细胞外区域; • soma; • 细胞外空间;
生物学过程	• response to cocaine; • response to immobilization stress; • positive regulation of cortisol secretion; • steroid metabolic process; • positive regulation of protein phosphorylation; • negative regulation of luteinizing hormone secretion; • positive regulation of cell death; • 联想型学习; • ion homeostasis; • lung development; • diterpenoid metabolic process; • response to corticosterone; • female pregnancy; • negative regulation of norepinephrine secretion; • adrenal gland development; • synaptic transmission, dopaminergic; • negative regulation of cell death; • negative regulation of gene expression; • cellular response to dexamethasone stimulus; • positive regulation of corticosterone secretion; • response to estrogen; • locomotory exploration behavior; • regulation of NMDA receptor activity; • regulation of serotonin secretion; • positive regulation of calcium ion import; • glucocorticoid biosynthetic process; • positive regulation of gene expression; • positive regulation of digestive system process; • 出生; • response to pain; • positive regulation of circadian sleep/wake cycle, wakefulness; • positive regulation of cell population proliferation; • 下丘脑的发生; • 学习和记忆; • hormone-mediated apoptotic signaling pathway; • positive regulation of insulin secretion involved in cellular response to glucose stimulus; • response to ethanol; • inflammatory response; • negative regulation of circadian sleep/wake cycle, REM sleep; • response to ether; • positive regulation of behavioral fear response; • 信号转导; • cellular response to cocaine; • 长时程增强作用; • 化学性突触传递; • negative regulation of epinephrine secretion; • negative regulation of glucagon secretion; • G protein-coupled receptor signaling pathway; • negative regulation of systemic arterial blood pressure; • positive regulation of cAMP-mediated signaling; • positive regulation of corticotropin secretion;
	Sources:Amigo / QuickGO
直系同源
	1392
	12918
	ENSG00000147571
	ENSMUSG00000049796
	P06850
	Q8CIT0
	NM_000756
	NM_205769
	NP_000747
	NP_991338
	维基数据
查看/编辑人类	查看/编辑小鼠

促肾上腺皮质素释放素是一种能参与应激反应的肽激素，也是一种释放激素（英语：Releasing and inhibiting hormones）。人类的促肾上腺皮质素释放素由CRH基因编码。 ^[5]促肾上腺皮质素释放素主要功能是可以刺激垂体合成促肾上腺皮质激素。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000147571 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000049796 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: CRH corticotropin releasing hormone.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000147571 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000049796 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Entrez Gene: CRH corticotropin releasing hormone.

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