丙基吡唑三醇

丙基吡唑三醇
识别信息
	IUPAC命名法 4-[2,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one; ;
CAS号	263717-53-9
PubChem CID	6095481;
ChemSpider	16142497;
UNII	0T83Y6JZPF;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID9040392 ;
化学信息
化学式	C24H22N2O3
摩尔质量	386.45 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCCC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O;
	InChI InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3; Key:UOSWGERPQQOSHS-UHFFFAOYSA-N;

丙基吡唑三醇（Propylpyrazoletriol，PPT），是一种合成非甾体 ERα 激动剂，选择性是ERβ的400倍^[1]，常用于研究ERα的功能。^[2]^[3]^[4]最初科学家认为PPT对ERα有高度选择性，唯后来发现PPT也可作GPER（G蛋白偶联雌激素受体1，GPR30）激动剂。^[5]

参见

参考文献

^ Ottow, Eckhard; Weinmann, Hilmar. Nuclear Receptors as Drug Targets. John Wiley & Sons. 8 September 2008: 50– [2022-03-23]. ISBN 978-3-527-62330-3. （原始内容存档于2022-03-23）.
^ Plant, Tony M.; Zeleznik, Anthony J. Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Academic Press. 15 November 2014: 2311– [2022-03-23]. ISBN 978-0-12-397769-4. （原始内容存档于2022-03-23）.
^ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012: 220– [2022-03-23]. ISBN 978-1-4649-9741-9. （原始内容存档于2022-05-04）.
^ Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (PROTACS).. 2008: 11–. ISBN 978-0-549-90990-3.
^ Estrogen biology: new insights into GPER function and clinical opportunities. Molecular and Cellular Endocrinology. May 2014, 389 (1–2): 71–83. PMC 4040308 . PMID 24530924. doi:10.1016/j.mce.2014.02.002.

[OttowWeinmann2008-1] Ottow, Eckhard; Weinmann, Hilmar. Nuclear Receptors as Drug Targets. John Wiley & Sons. 8 September 2008: 50– [2022-03-23]. ISBN 978-3-527-62330-3. （原始内容存档于2022-03-23）.

[PlantZeleznik2014-2] Plant, Tony M.; Zeleznik, Anthony J. Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Academic Press. 15 November 2014: 2311– [2022-03-23]. ISBN 978-0-12-397769-4. （原始内容存档于2022-03-23）.

[3] Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012: 220– [2022-03-23]. ISBN 978-1-4649-9741-9. （原始内容存档于2022-05-04）.

[4] Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (PROTACS).. 2008: 11–. ISBN 978-0-549-90990-3.

[ProssnitzBarton2014-5] Estrogen biology: new insights into GPER function and clinical opportunities. Molecular and Cellular Endocrinology. May 2014, 389 (1–2): 71–83. PMC 4040308 . PMID 24530924. doi:10.1016/j.mce.2014.02.002.

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