N-甲基-D-天门冬氨酸受体

N-甲基-D-天冬氨酸受体（N-methyl-D-aspartate receptor，NMDAR），简称NMDA受体，为谷氨酸盐受体，是一个主要的分子装置，控制突触的可塑性与记忆功能^[2]。

NMDA受体是一种离子型谷氨酸盐受体的特别型态。NMDA（N-甲基-D-天冬氨酸）是一种选择性致效剂，可以与NMDA受体结合，但是无法和其他谷氨酸盐受体结合。NMDA受体的结合，会导致离子通道非选择性地开启，使阳离子通过，进而使平衡电位改变至接近0毫伏特。NMDA受体进行激活，必须依赖电压，这会导致离子通道会阻挡细胞外的Mg²⁺与Zn²⁺离子通过，并允许Na⁺离子与少量Ca²⁺离子流入细胞，以及使K⁺离子流出细胞，并保持电压的依赖性^[3]^[4]^[5]^[6]。

参见

参考文献

^ Laube B, Hirai H, Sturgess M, Betz H, Kuhse J. Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron. 1997, 18 (3): 493–503. PMID 9115742. doi:10.1016/S0896-6273(00)81249-0.
^ Li F, Tsien JZ. Memory and the NMDA receptors. N. Engl. J. Med. 2009, 361 (3): 302–3. PMC 3703758 . PMID 19605837. doi:10.1056/NEJMcibr0902052.
^ Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate receptor ion channels. Pharmacol. Rev. March 1999, 51 (1): 7–61 [2014-04-27]. PMID 10049997. （原始内容存档于2020-10-27）.
^ Liu Y, Zhang J. Recent development in NMDA receptors. Chin. Med. J. October 2000, 113 (10): 948–56 [2014-04-27]. PMID 11775847. （原始内容存档于2014-04-27）.
^ Cull-Candy S, Brickley S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. June 2001, 11 (3): 327–35 [2014-04-27]. PMID 11399431. doi:10.1016/S0959-4388(00)00215-4. （原始内容存档于2020-07-24）.
^ Paoletti P, Neyton J. NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol. February 2007, 7 (1): 39–47. PMID 17088105. doi:10.1016/j.coph.2006.08.011.

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[Laube-1] Laube B, Hirai H, Sturgess M, Betz H, Kuhse J. Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron. 1997, 18 (3): 493–503. PMID 9115742. doi:10.1016/S0896-6273(00)81249-0.

[pmid19605837-2] Li F, Tsien JZ. Memory and the NMDA receptors. N. Engl. J. Med. 2009, 361 (3): 302–3. PMC 3703758 . PMID 19605837. doi:10.1056/NEJMcibr0902052.

[pmid10049997-3] Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate receptor ion channels. Pharmacol. Rev. March 1999, 51 (1): 7–61 [2014-04-27]. PMID 10049997. （原始内容存档于2020-10-27）.

[pmid11775847-4] Liu Y, Zhang J. Recent development in NMDA receptors. Chin. Med. J. October 2000, 113 (10): 948–56 [2014-04-27]. PMID 11775847. （原始内容存档于2014-04-27）.

[pmid11399431-5] Cull-Candy S, Brickley S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. June 2001, 11 (3): 327–35 [2014-04-27]. PMID 11399431. doi:10.1016/S0959-4388(00)00215-4. （原始内容存档于2020-07-24）.

[pmid17088105-6] Paoletti P, Neyton J. NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol. February 2007, 7 (1): 39–47. PMID 17088105. doi:10.1016/j.coph.2006.08.011.

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